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MELK maternal embryonic leucine zipper kinase [ Homo sapiens (human) ]

Gene ID: 9833, updated on 2-Nov-2024

Summary

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Official Symbol
MELKprovided by HGNC
Official Full Name
maternal embryonic leucine zipper kinaseprovided by HGNC
Primary source
HGNC:HGNC:16870
See related
Ensembl:ENSG00000165304 MIM:607025; AllianceGenome:HGNC:16870
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HPK38
Summary
Enables calcium ion binding activity; non-membrane spanning protein tyrosine kinase activity; and protein serine/threonine kinase activity. Involved in apoptotic process; cell population proliferation; and protein autophosphorylation. Located in cell cortex and plasma membrane. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in testis (RPKM 5.2), lymph node (RPKM 4.4) and 14 other tissues See more
Orthologs
mouse all
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Genomic context

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See MELK in Genome Data Viewer
Location:
9p13.2
Exon count:
20
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 9 NC_000009.12 (36572895..36677682)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 9 NC_060933.1 (36595568..36700421)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (36572892..36677679)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102724322 Neighboring gene high mobility group box 3 pseudogene 24 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:36391761-36392261 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28350 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19892 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19893 Neighboring gene uncharacterized LOC124902152 Neighboring gene ring finger protein 38 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr9:36415685-36416307 Neighboring gene mitochondrial ribosomal protein S21 pseudogene 4 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28352 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28351 Neighboring gene ReSE screen-validated silencer GRCh37_chr9:36482565-36482744 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19894 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19895 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28353 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28354 Neighboring gene H3K27ac hESC enhancer GRCh37_chr9:36558262-36558872 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:36571611-36572110 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19896 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:36584821-36585797 Neighboring gene ReSE screen-validated silencer GRCh37_chr9:36596422-36596589 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28355 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:36725931-36726432 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr9:36738402-36739601 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19897 Neighboring gene ReSE screen-validated silencer GRCh37_chr9:36756569-36756775 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:36764829-36765347 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:36764310-36764828 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28356 Neighboring gene uncharacterized LOC105376030 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19898 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:36820286-36820786 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:36848015-36848854 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr9:36851359-36852558 Neighboring gene microRNA 4475 Neighboring gene paired box 5 Neighboring gene microRNA 4540

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. MELK is an oncogenic kinase essential for early hepatocellular carcinoma recurrence. Xia H, et al. Cancer Lett, 2016 Dec 1. PMID 27693640
  2. Preclinical efficacy of maternal embryonic leucine-zipper kinase (MELK) inhibition in acute myeloid leukemia. Alachkar H, et al. Oncotarget, 2014 Dec 15. PMID 25365263, Free PMC Article
  3. Discovery of a new molecule inducing melanoma cell death: dual AMPK/MELK targeting for novel melanoma therapies. Jaune E, et al. Cell Death Dis, 2021 Jan 11. PMID 33431809, Free PMC Article
  4. MELK is an oncogenic kinase essential for metastasis, mitotic progression, and programmed death in lung carcinoma. Tang Q, et al. Signal Transduct Target Ther, 2020 Dec 2. PMID 33262323, Free PMC Article
  5. MELK/MPK38 in cancer: from mechanistic aspects to therapeutic strategies. Thangaraj K, et al. Drug Discov Today, 2020 Dec. PMID 33010478

See all (103) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. MELK aggravates lung adenocarcinoma by regulating EZH2 ubiquitination and H3K27me3 histone methylation of LATS2.
    Title: MELK aggravates lung adenocarcinoma by regulating EZH2 ubiquitination and H3K27me3 histone methylation of LATS2.
  2. Exploration of MELK as a downstream of Del-1 and druggable targets in triple-negative breast cancer.
    Title: Exploration of MELK as a downstream of Del-1 and druggable targets in triple-negative breast cancer.
  3. Decoding the significant diagnostic and prognostic importance of maternal embryonic leucine zipper kinase in human cancers through deep integrative analyses.
    Title: Decoding the significant diagnostic and prognostic importance of maternal embryonic leucine zipper kinase in human cancers through deep integrative analyses.
  4. Cyclosporin A inhibits prostate cancer growth through suppression of E2F8 transcription factor in a MELK-dependent manner.
    Title: Cyclosporin A inhibits prostate cancer growth through suppression of E2F8 transcription factor in a MELK‑dependent manner.
  5. Maternal Embryonic Leucine Zipper Kinase is Associated with Metastasis in Triple-negative Breast Cancer.
    Title: Maternal Embryonic Leucine Zipper Kinase is Associated with Metastasis in Triple-negative Breast Cancer.
  6. ANKRD22 promotes glioma proliferation, migration, invasion, and epithelial-mesenchymal transition by upregulating E2F1-mediated MELK expression.
    Title: ANKRD22 promotes glioma proliferation, migration, invasion, and epithelial-mesenchymal transition by upregulating E2F1-mediated MELK expression.
  7. Differential Effects of Overexpression of Wild Type and Kinase-Dead MELK in Fibroblasts and Keratinocytes, Potential Implications for Skin Wound Healing and Cancer.
    Title: Differential Effects of Overexpression of Wild Type and Kinase-Dead MELK in Fibroblasts and Keratinocytes, Potential Implications for Skin Wound Healing and Cancer.
  8. Circular RNA MELK Promotes Chondrocyte Apoptosis and Inhibits Autophagy in Osteoarthritis by Regulating MYD88/NF-kappaB Signaling Axis through MicroRNA-497-5p.
    Title: Circular RNA MELK Promotes Chondrocyte Apoptosis and Inhibits Autophagy in Osteoarthritis by Regulating MYD88/NF-κB Signaling Axis through MicroRNA-497-5p.
  9. LncRNA OSTM1-AS1 acts as an oncogenic factor in Wilms' tumor by regulating the miR-514a-3p/MELK axis.
    Title: LncRNA OSTM1-AS1 acts as an oncogenic factor in Wilms' tumor by regulating the miR-514a-3p/MELK axis.
  10. Subtype-specific expression of MELK is partly due to copy number alterations in breast cancer.
    Title: Subtype-specific expression of MELK is partly due to copy number alterations in breast cancer.
Submit: New GeneRIF Correction See all GeneRIFs (63)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
Tat tat HIV-1 Tat-peptide(48-60) inhibits AGC-family kinases (PKB, SGK1, S6K1, MSK1), CAMK-family kinases (CAMK1 and MELK) and a STE family kinase (MKK1) PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • KIAA0175

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables calcium ion binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables histone H2AS1 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables lipid binding IEA
Inferred from Electronic Annotation
more info
  
enables non-membrane spanning protein tyrosine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables non-membrane spanning protein tyrosine kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in G2/M transition of mitotic cell cycle TAS
Traceable Author Statement
more info
 PubMed 
involved_in apoptotic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in cell population proliferation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in chromatin remodeling IEA
Inferred from Electronic Annotation
more info
  
involved_in hemopoiesis ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in intrinsic apoptotic signaling pathway in response to oxidative stress IEA
Inferred from Electronic Annotation
more info
  
involved_in neural precursor cell proliferation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of apoptotic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in protein autophosphorylation IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in cell cortex IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane HDA PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
maternal embryonic leucine zipper kinase
Names
pEg3 kinase
protein kinase Eg3
protein kinase PK38
tyrosine-protein kinase MELK
NP_001243614.1
NP_001243616.1
NP_001243617.1
NP_001243618.1
NP_001243619.1
NP_001243620.1
NP_001243621.1
NP_001243622.1
NP_055606.1
XP_011516378.1
XP_011516379.1
XP_011516382.1
XP_011516383.1
XP_011516384.1
XP_011516387.1
XP_047280122.1
XP_047280124.1
XP_047280125.1
XP_047280126.1
XP_047280127.1
XP_047280128.1
XP_047280129.1
XP_047280130.1
XP_047280132.1
XP_047280133.1
XP_047280134.1
XP_047280135.1
XP_047280136.1
XP_047280137.1
XP_047280138.1
XP_047280139.1
XP_047280140.1
XP_047280141.1
XP_047280142.1
XP_047280143.1
XP_047280144.1
XP_047280145.1
XP_047280147.1
XP_047280148.1
XP_047280149.1
XP_047280150.1
XP_047280151.1
XP_047280152.1
XP_047280153.1
XP_047280154.1
XP_047280155.1
XP_047280156.1
XP_047280158.1
XP_047280159.1
XP_047280160.1
XP_047280161.1
XP_047280162.1
XP_054220272.1
XP_054220273.1
XP_054220274.1
XP_054220275.1
XP_054220276.1
XP_054220277.1
XP_054220278.1
XP_054220279.1
XP_054220280.1
XP_054220281.1
XP_054220282.1
XP_054220283.1
XP_054220284.1
XP_054220285.1
XP_054220286.1
XP_054220287.1
XP_054220288.1
XP_054220289.1
XP_054220290.1
XP_054220291.1
XP_054220292.1
XP_054220293.1
XP_054220294.1
XP_054220295.1
XP_054220296.1
XP_054220297.1
XP_054220298.1
XP_054220299.1
XP_054220300.1
XP_054220301.1
XP_054220302.1
XP_054220303.1
XP_054220304.1
XP_054220305.1
XP_054220306.1
XP_054220307.1
XP_054220308.1
XP_054220309.1
XP_054220310.1
XP_054220311.1
XP_054220312.1
XP_054220313.1
XP_054220314.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001256685.2 → NP_001243614.1  maternal embryonic leucine zipper kinase isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an exon in the 3' coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AI590871, AK299164, BC014039, BP365611
    Consensus CDS
    CCDS59123.1
    UniProtKB/TrEMBL
    Q53GX0
    Related
    ENSP00000437804.1, ENST00000541717.4
    Conserved Domains (4) summary
    cd12198
    Location:514 → 608
    MELK_C; C-terminal kinase associated domain 1 (KA1) of Maternal embryonic leucine zipper kinase
    smart00220
    Location:11 → 263
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14341
    Location:281 → 332
    UBA_MELK; UBA domain found in maternal embryonic leucine zipper kinase (MELK) and similar proteins
    cd14078
    Location:7 → 263
    STKc_MELK; Catalytic domain of the Serine/Threonine Kinase, Maternal Embryonic Leucine zipper Kinase

  2. NM_001256687.2 → NP_001243616.1  maternal embryonic leucine zipper kinase isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an exon in the 5' coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (3) is shorter than isoform 1.
    Source sequence(s)
    AI590871, AK300761, BC014039, BP365611
    Consensus CDS
    CCDS59124.1
    UniProtKB/TrEMBL
    Q53GX0
    Related
    ENSP00000439792.1, ENST00000536860.5
    Conserved Domains (4) summary
    cd12198
    Location:507 → 601
    MELK_C; C-terminal kinase associated domain 1 (KA1) of Maternal embryonic leucine zipper kinase
    smart00220
    Location:11 → 215
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14341
    Location:233 → 284
    UBA_MELK; UBA domain found in maternal embryonic leucine zipper kinase (MELK) and similar proteins
    cl21453
    Location:7 → 215
    PKc_like; Protein Kinases, catalytic domain

  3. NM_001256688.2 → NP_001243617.1  maternal embryonic leucine zipper kinase isoform 4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks two consecutive exons in the 5' coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (4) is shorter than isoform 1.
    Source sequence(s)
    AI590871, AK293284, BC014039, BP365611
    Consensus CDS
    CCDS59125.1
    UniProtKB/TrEMBL
    Q53GX0
    Related
    ENSP00000445452.1, ENST00000545008.5
    Conserved Domains (4) summary
    cd12198
    Location:484 → 578
    MELK_C; C-terminal kinase associated domain 1 (KA1) of Maternal embryonic leucine zipper kinase
    smart00220
    Location:11 → 192
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14341
    Location:210 → 261
    UBA_MELK; UBA domain found in maternal embryonic leucine zipper kinase (MELK) and similar proteins
    cl21453
    Location:7 → 192
    PKc_like; Protein Kinases, catalytic domain

  4. NM_001256689.2 → NP_001243618.1  maternal embryonic leucine zipper kinase isoform 5

    See identical proteins and their annotated locations for NP_001243618.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) initiates translation at an alternate start codon and lacks an exon in the 5' coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (5) is shorter and has a distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AB183427, AI590871, BP365611
    Consensus CDS
    CCDS59126.1
    UniProtKB/TrEMBL
    Q53GX0
    Related
    ENSP00000441596.1, ENST00000543751.5
    Conserved Domains (4) summary
    cd12198
    Location:523 → 617
    MELK_C; C-terminal kinase associated domain 1 (KA1) of Maternal embryonic leucine zipper kinase
    smart00220
    Location:17 → 231
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14341
    Location:249 → 300
    UBA_MELK; UBA domain found in maternal embryonic leucine zipper kinase (MELK) and similar proteins
    cl21453
    Location:7 → 231
    PKc_like; Protein Kinases, catalytic domain

  5. NM_001256690.2 → NP_001243619.1  maternal embryonic leucine zipper kinase isoform 6

    See identical proteins and their annotated locations for NP_001243619.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) initiates translation at an alternate start codon and lacks two consecutive exons in the 5' coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (6) is shorter and has a distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AB183428, AI590871, BP365611
    Consensus CDS
    CCDS59127.1
    UniProtKB/TrEMBL
    Q53GX0
    Related
    ENSP00000443550.1, ENST00000536329.5
    Conserved Domains (4) summary
    cd12198
    Location:484 → 578
    MELK_C; C-terminal kinase associated domain 1 (KA1) of Maternal embryonic leucine zipper kinase
    smart00220
    Location:9 → 192
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14341
    Location:210 → 261
    UBA_MELK; UBA domain found in maternal embryonic leucine zipper kinase (MELK) and similar proteins
    cl21453
    Location:10 → 192
    PKc_like; Protein Kinases, catalytic domain

  6. NM_001256691.2 → NP_001243620.1  maternal embryonic leucine zipper kinase isoform 7

    See identical proteins and their annotated locations for NP_001243620.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7) initiates translation at an alternate start codon and lacks two exons in the 5' coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (7) is shorter and has a distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AI590871, AK293423, BP365611, W01871
    UniProtKB/TrEMBL
    B7Z1G6, Q53GX0
    Conserved Domains (4) summary
    cd12198
    Location:475 → 569
    MELK_C; C-terminal kinase associated domain 1 (KA1) of Maternal embryonic leucine zipper kinase
    smart00220
    Location:17 → 183
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14341
    Location:201 → 252
    UBA_MELK; UBA domain found in maternal embryonic leucine zipper kinase (MELK) and similar proteins
    cl21453
    Location:7 → 183
    PKc_like; Protein Kinases, catalytic domain

  7. NM_001256692.2 → NP_001243621.1  maternal embryonic leucine zipper kinase isoform 8

    See identical proteins and their annotated locations for NP_001243621.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (8) lacks three exons in the 5' coding region and initiates translation at a downstream, in-frame start codon, compared to variant 1. The encoded isoform (8) has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AI590871, AK302374, DB368226
    Consensus CDS
    CCDS59128.1
    UniProtKB/TrEMBL
    B7Z450
    Related
    ENSP00000439184.1, ENST00000536987.5
    Conserved Domains (4) summary
    cd12198
    Location:424 → 518
    MELK_C; C-terminal kinase associated domain 1 (KA1) of Maternal embryonic leucine zipper kinase
    smart00220
    Location:5 → 132
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14341
    Location:150 → 201
    UBA_MELK; UBA domain found in maternal embryonic leucine zipper kinase (MELK) and similar proteins
    cl21453
    Location:5 → 132
    PKc_like; Protein Kinases, catalytic domain

  8. NM_001256693.2 → NP_001243622.1  maternal embryonic leucine zipper kinase isoform 9

    See identical proteins and their annotated locations for NP_001243622.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (9) lacks two consecutive exons in the 5' region and initiates translation at a downstream, in-frame start codon, compared to variant 1. The encoded isoform (9) has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AI590871, AK301131, BP365611, W01871
    UniProtKB/TrEMBL
    B7Z450
    Conserved Domains (3) summary
    cd12198
    Location:361 → 455
    MELK_C; C-terminal kinase associated domain 1 (KA1) of Maternal embryonic leucine zipper kinase
    cd14341
    Location:87 → 138
    UBA_MELK; UBA domain found in maternal embryonic leucine zipper kinase (MELK) and similar proteins
    cl21453
    Location:1 → 69
    PKc_like; Protein Kinases, catalytic domain

  9. NM_014791.4 → NP_055606.1  maternal embryonic leucine zipper kinase isoform 1

    See identical proteins and their annotated locations for NP_055606.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AI590871, D79997, DB368226
    Consensus CDS
    CCDS6606.1
    UniProtKB/Swiss-Prot
    A6P3A7, A6P3A8, B1AMQ6, B7Z1E6, B7Z5M5, B7Z6Q7, B7Z6R8, B7Z6Y0, B7Z7Q1, D3DRP8, F5H0Y0, F5H2R4, F5H689, Q14680, Q7L3C3
    UniProtKB/TrEMBL
    Q53GX0
    Related
    ENSP00000298048.2, ENST00000298048.7
    Conserved Domains (4) summary
    cd12198
    Location:555 → 649
    MELK_C; C-terminal kinase associated domain 1 (KA1) of Maternal embryonic leucine zipper kinase
    smart00220
    Location:11 → 263
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14341
    Location:281 → 332
    UBA_MELK; UBA domain found in maternal embryonic leucine zipper kinase (MELK) and similar proteins
    cd14078
    Location:7 → 263
    STKc_MELK; Catalytic domain of the Serine/Threonine Kinase, Maternal Embryonic Leucine zipper Kinase

RNA

  1. NR_046337.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (10) lacks an internal exon and contains an alternate internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AI590871, AK296820, BC014039
    Related
    ENST00000627766.2

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p14 Primary Assembly

    Range
    36572895..36677682
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011518076.3 → XP_011516378.1  maternal embryonic leucine zipper kinase isoform X1

    See identical proteins and their annotated locations for XP_011516378.1

    UniProtKB/Swiss-Prot
    A6P3A7, A6P3A8, B1AMQ6, B7Z1E6, B7Z5M5, B7Z6Q7, B7Z6R8, B7Z6Y0, B7Z7Q1, D3DRP8, F5H0Y0, F5H2R4, F5H689, Q14680, Q7L3C3
    UniProtKB/TrEMBL
    Q53GX0
    Conserved Domains (4) summary
    cd12198
    Location:555 → 649
    MELK_C; C-terminal kinase associated domain 1 (KA1) of Maternal embryonic leucine zipper kinase
    smart00220
    Location:11 → 263
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14341
    Location:281 → 332
    UBA_MELK; UBA domain found in maternal embryonic leucine zipper kinase (MELK) and similar proteins
    cd14078
    Location:7 → 263
    STKc_MELK; Catalytic domain of the Serine/Threonine Kinase, Maternal Embryonic Leucine zipper Kinase

  2. XM_047424171.1 → XP_047280127.1  maternal embryonic leucine zipper kinase isoform X4

  3. XM_047424168.1 → XP_047280124.1  maternal embryonic leucine zipper kinase isoform X2

  4. XM_047424180.1 → XP_047280136.1  maternal embryonic leucine zipper kinase isoform X7

  5. XM_047424173.1 → XP_047280129.1  maternal embryonic leucine zipper kinase isoform X5

  6. XM_047424192.1 → XP_047280148.1  maternal embryonic leucine zipper kinase isoform X12

  7. XM_047424185.1 → XP_047280141.1  maternal embryonic leucine zipper kinase isoform X9

  8. XM_011518082.3 → XP_011516384.1  maternal embryonic leucine zipper kinase isoform X3

    See identical proteins and their annotated locations for XP_011516384.1

    UniProtKB/TrEMBL
    Q53GX0
    Conserved Domains (4) summary
    cd12198
    Location:523 → 617
    MELK_C; C-terminal kinase associated domain 1 (KA1) of Maternal embryonic leucine zipper kinase
    smart00220
    Location:17 → 231
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14341
    Location:249 → 300
    UBA_MELK; UBA domain found in maternal embryonic leucine zipper kinase (MELK) and similar proteins
    cl21453
    Location:7 → 231
    PKc_like; Protein Kinases, catalytic domain

  9. XM_047424182.1 → XP_047280138.1  maternal embryonic leucine zipper kinase isoform X8

  10. XM_047424177.1 → XP_047280133.1  maternal embryonic leucine zipper kinase isoform X6

  11. XM_047424195.1 → XP_047280151.1  maternal embryonic leucine zipper kinase isoform X13

  12. XM_047424187.1 → XP_047280143.1  maternal embryonic leucine zipper kinase isoform X10

    UniProtKB/TrEMBL
    B7Z1G6

  13. XM_047424204.1 → XP_047280160.1  maternal embryonic leucine zipper kinase isoform X17

  14. XM_047424166.1 → XP_047280122.1  maternal embryonic leucine zipper kinase isoform X1

    UniProtKB/Swiss-Prot
    A6P3A7, A6P3A8, B1AMQ6, B7Z1E6, B7Z5M5, B7Z6Q7, B7Z6R8, B7Z6Y0, B7Z7Q1, D3DRP8, F5H0Y0, F5H2R4, F5H689, Q14680, Q7L3C3

  15. XM_011518077.2 → XP_011516379.1  maternal embryonic leucine zipper kinase isoform X1

    See identical proteins and their annotated locations for XP_011516379.1

    UniProtKB/Swiss-Prot
    A6P3A7, A6P3A8, B1AMQ6, B7Z1E6, B7Z5M5, B7Z6Q7, B7Z6R8, B7Z6Y0, B7Z7Q1, D3DRP8, F5H0Y0, F5H2R4, F5H689, Q14680, Q7L3C3
    UniProtKB/TrEMBL
    Q53GX0
    Conserved Domains (4) summary
    cd12198
    Location:555 → 649
    MELK_C; C-terminal kinase associated domain 1 (KA1) of Maternal embryonic leucine zipper kinase
    smart00220
    Location:11 → 263
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14341
    Location:281 → 332
    UBA_MELK; UBA domain found in maternal embryonic leucine zipper kinase (MELK) and similar proteins
    cd14078
    Location:7 → 263
    STKc_MELK; Catalytic domain of the Serine/Threonine Kinase, Maternal Embryonic Leucine zipper Kinase

  16. XM_047424170.1 → XP_047280126.1  maternal embryonic leucine zipper kinase isoform X4

  17. XM_047424169.1 → XP_047280125.1  maternal embryonic leucine zipper kinase isoform X2

  18. XM_047424179.1 → XP_047280135.1  maternal embryonic leucine zipper kinase isoform X7

  19. XM_047424172.1 → XP_047280128.1  maternal embryonic leucine zipper kinase isoform X5

  20. XM_047424191.1 → XP_047280147.1  maternal embryonic leucine zipper kinase isoform X12

  21. XM_047424186.1 → XP_047280142.1  maternal embryonic leucine zipper kinase isoform X9

  22. XM_047424200.1 → XP_047280156.1  maternal embryonic leucine zipper kinase isoform X16

  23. XM_011518081.3 → XP_011516383.1  maternal embryonic leucine zipper kinase isoform X3

    See identical proteins and their annotated locations for XP_011516383.1

    UniProtKB/TrEMBL
    Q53GX0
    Conserved Domains (4) summary
    cd12198
    Location:523 → 617
    MELK_C; C-terminal kinase associated domain 1 (KA1) of Maternal embryonic leucine zipper kinase
    smart00220
    Location:17 → 231
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14341
    Location:249 → 300
    UBA_MELK; UBA domain found in maternal embryonic leucine zipper kinase (MELK) and similar proteins
    cl21453
    Location:7 → 231
    PKc_like; Protein Kinases, catalytic domain

  24. XM_047424183.1 → XP_047280139.1  maternal embryonic leucine zipper kinase isoform X8

  25. XM_047424176.1 → XP_047280132.1  maternal embryonic leucine zipper kinase isoform X6

  26. XM_047424193.1 → XP_047280149.1  maternal embryonic leucine zipper kinase isoform X13

  27. XM_047424188.1 → XP_047280144.1  maternal embryonic leucine zipper kinase isoform X10

    UniProtKB/TrEMBL
    B7Z1G6

  28. XM_047424203.1 → XP_047280159.1  maternal embryonic leucine zipper kinase isoform X17

  29. XM_047424197.1 → XP_047280153.1  maternal embryonic leucine zipper kinase isoform X14

  30. XM_011518080.1 → XP_011516382.1  maternal embryonic leucine zipper kinase isoform X2

    UniProtKB/TrEMBL
    Q53GX0
    Conserved Domains (3) summary
    cd12198
    Location:526 → 620
    MELK_C; C-terminal kinase associated domain 1 (KA1) of Maternal embryonic leucine zipper kinase
    smart00220
    Location:11 → 263
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14078
    Location:7 → 263
    STKc_MELK; Catalytic domain of the Serine/Threonine Kinase, Maternal Embryonic Leucine zipper Kinase

  31. XM_047424178.1 → XP_047280134.1  maternal embryonic leucine zipper kinase isoform X7

  32. XM_047424189.1 → XP_047280145.1  maternal embryonic leucine zipper kinase isoform X12

  33. XM_047424184.1 → XP_047280140.1  maternal embryonic leucine zipper kinase isoform X9

  34. XM_047424199.1 → XP_047280155.1  maternal embryonic leucine zipper kinase isoform X16

  35. XM_047424181.1 → XP_047280137.1  maternal embryonic leucine zipper kinase isoform X8

  36. XM_047424174.1 → XP_047280130.1  maternal embryonic leucine zipper kinase isoform X6

  37. XM_047424194.1 → XP_047280150.1  maternal embryonic leucine zipper kinase isoform X13

  38. XM_047424202.1 → XP_047280158.1  maternal embryonic leucine zipper kinase isoform X17

  39. XM_047424196.1 → XP_047280152.1  maternal embryonic leucine zipper kinase isoform X14

  40. XM_047424206.1 → XP_047280162.1  maternal embryonic leucine zipper kinase isoform X19

  41. XM_011518085.2 → XP_011516387.1  maternal embryonic leucine zipper kinase isoform X11

    UniProtKB/TrEMBL
    Q53GX0
    Conserved Domains (4) summary
    cd12198
    Location:472 → 566
    MELK_C; C-terminal kinase associated domain 1 (KA1) of Maternal embryonic leucine zipper kinase
    smart00220
    Location:1 → 180
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14341
    Location:198 → 249
    UBA_MELK; UBA domain found in maternal embryonic leucine zipper kinase (MELK) and similar proteins
    cl21453
    Location:1 → 180
    PKc_like; Protein Kinases, catalytic domain

  42. XM_047424205.1 → XP_047280161.1  maternal embryonic leucine zipper kinase isoform X18

  43. XM_047424198.1 → XP_047280154.1  maternal embryonic leucine zipper kinase isoform X15

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060933.1 Alternate T2T-CHM13v2.0

    Range
    36595568..36700421
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054364299.1 → XP_054220274.1  maternal embryonic leucine zipper kinase isoform X1

    UniProtKB/Swiss-Prot
    A6P3A7, A6P3A8, B1AMQ6, B7Z1E6, B7Z5M5, B7Z6Q7, B7Z6R8, B7Z6Y0, B7Z7Q1, D3DRP8, F5H0Y0, F5H2R4, F5H689, Q14680, Q7L3C3

  2. XM_054364304.1 → XP_054220279.1  maternal embryonic leucine zipper kinase isoform X3

  3. XM_054364317.1 → XP_054220292.1  maternal embryonic leucine zipper kinase isoform X8

  4. XM_054364306.1 → XP_054220281.1  maternal embryonic leucine zipper kinase isoform X4

  5. XM_054364314.1 → XP_054220289.1  maternal embryonic leucine zipper kinase isoform X7

  6. XM_054364308.1 → XP_054220283.1  maternal embryonic leucine zipper kinase isoform X5

  7. XM_054364322.1 → XP_054220297.1  maternal embryonic leucine zipper kinase isoform X10

    UniProtKB/TrEMBL
    B7Z1G6

  8. XM_054364337.1 → XP_054220312.1  maternal embryonic leucine zipper kinase isoform X17

  9. XM_054364301.1 → XP_054220276.1  maternal embryonic leucine zipper kinase isoform X2

  10. XM_054364319.1 → XP_054220294.1  maternal embryonic leucine zipper kinase isoform X9

  11. XM_054364329.1 → XP_054220304.1  maternal embryonic leucine zipper kinase isoform X13

  12. XM_054364326.1 → XP_054220301.1  maternal embryonic leucine zipper kinase isoform X12

  13. XM_054364311.1 → XP_054220286.1  maternal embryonic leucine zipper kinase isoform X6

  14. XM_054364297.1 → XP_054220272.1  maternal embryonic leucine zipper kinase isoform X1

    UniProtKB/Swiss-Prot
    A6P3A7, A6P3A8, B1AMQ6, B7Z1E6, B7Z5M5, B7Z6Q7, B7Z6R8, B7Z6Y0, B7Z7Q1, D3DRP8, F5H0Y0, F5H2R4, F5H689, Q14680, Q7L3C3

  15. XM_054364298.1 → XP_054220273.1  maternal embryonic leucine zipper kinase isoform X1

    UniProtKB/Swiss-Prot
    A6P3A7, A6P3A8, B1AMQ6, B7Z1E6, B7Z5M5, B7Z6Q7, B7Z6R8, B7Z6Y0, B7Z7Q1, D3DRP8, F5H0Y0, F5H2R4, F5H689, Q14680, Q7L3C3

  16. XM_054364305.1 → XP_054220280.1  maternal embryonic leucine zipper kinase isoform X4

  17. XM_054364302.1 → XP_054220277.1  maternal embryonic leucine zipper kinase isoform X2

  18. XM_054364313.1 → XP_054220288.1  maternal embryonic leucine zipper kinase isoform X7

  19. XM_054364307.1 → XP_054220282.1  maternal embryonic leucine zipper kinase isoform X5

  20. XM_054364325.1 → XP_054220300.1  maternal embryonic leucine zipper kinase isoform X12

  21. XM_054364320.1 → XP_054220295.1  maternal embryonic leucine zipper kinase isoform X9

  22. XM_054364334.1 → XP_054220309.1  maternal embryonic leucine zipper kinase isoform X16

  23. XM_054364303.1 → XP_054220278.1  maternal embryonic leucine zipper kinase isoform X3

  24. XM_054364316.1 → XP_054220291.1  maternal embryonic leucine zipper kinase isoform X8

  25. XM_054364310.1 → XP_054220285.1  maternal embryonic leucine zipper kinase isoform X6

  26. XM_054364327.1 → XP_054220302.1  maternal embryonic leucine zipper kinase isoform X13

  27. XM_054364321.1 → XP_054220296.1  maternal embryonic leucine zipper kinase isoform X10

    UniProtKB/TrEMBL
    B7Z1G6

  28. XM_054364336.1 → XP_054220311.1  maternal embryonic leucine zipper kinase isoform X17

  29. XM_054364331.1 → XP_054220306.1  maternal embryonic leucine zipper kinase isoform X14

  30. XM_054364300.1 → XP_054220275.1  maternal embryonic leucine zipper kinase isoform X2

  31. XM_054364312.1 → XP_054220287.1  maternal embryonic leucine zipper kinase isoform X7

  32. XM_054364324.1 → XP_054220299.1  maternal embryonic leucine zipper kinase isoform X12

  33. XM_054364318.1 → XP_054220293.1  maternal embryonic leucine zipper kinase isoform X9

  34. XM_054364333.1 → XP_054220308.1  maternal embryonic leucine zipper kinase isoform X16

  35. XM_054364315.1 → XP_054220290.1  maternal embryonic leucine zipper kinase isoform X8

  36. XM_054364309.1 → XP_054220284.1  maternal embryonic leucine zipper kinase isoform X6

  37. XM_054364328.1 → XP_054220303.1  maternal embryonic leucine zipper kinase isoform X13

  38. XM_054364335.1 → XP_054220310.1  maternal embryonic leucine zipper kinase isoform X17

  39. XM_054364330.1 → XP_054220305.1  maternal embryonic leucine zipper kinase isoform X14

  40. XM_054364339.1 → XP_054220314.1  maternal embryonic leucine zipper kinase isoform X19

  41. XM_054364323.1 → XP_054220298.1  maternal embryonic leucine zipper kinase isoform X11

  42. XM_054364338.1 → XP_054220313.1  maternal embryonic leucine zipper kinase isoform X18

  43. XM_054364332.1 → XP_054220307.1  maternal embryonic leucine zipper kinase isoform X15

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q14680.3 GenPept UniProtKB/Swiss-Prot:Q14680

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